产品货号：
Z24142
中文名称：
PSEN2抗体
英文名称：
Anti-PSEN2 Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-PSEN2 Antibody |
| 指标别名 | presenilin 2;AD3L;AD4;CMD1V;PS2;STM2;PSEN2 |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB,IHC,ICC/IF,FCM |
| 基因名称 | PSEN2 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | A synthetic peptide corresponding to a sequence of human Presenilin 2/AD5/PSEN2 (STDNLVRPFMDTLASHQLYI). |
| 实际分子量 | 34KD(cleaved),50KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | Presenilin-2 is a protein that in humans is encoded by the PSEN2 gene.Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP).These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains).Presenilins are postulated to regulate APP processing through their effects on gamma-secretase,an enzyme that cleaves APP.Also,it is thought that the presenilins are involved in the cleavage of the Notch receptor such that,they either directly regulate gamma-secretase activity,or themselves act are protease enzymes.Two alternatively spliced transcript variants encoding different isoforms of PSEN2 have been identified. |
| Uniprot ID | P49810 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot. |
| 基因名全称 | presenilin 2 |
| 蛋白名全称 | Presenilin-2 |
| 推荐稀释比 | Western blot(WB) 1:500～2000 Immunohistochemistry in paraffin section (IHC) 1:50～400 Immunocytochemistry/Immunofluorescence (ICC/IF) 1:50～400 Flow cytometry (FCM) 1～3μg/1×106 cells (Boiling the paraffin sections in 10mM citrate buffer,pH6.0,or PH8.0 EDTA repair liquid for 20 mins is required for the staining of formalin/paraffin sections.) Optimal working dilutions must be determined by end user. |
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